The La Crosse Method™ Protocol

At Allergy Associates of La Crosse, our sublingual immunotherapy treatment approach is based on the available international research and our more than 40 year history of clinical application in treating more than 125,000 patients with a wide variety of allergic conditions.

As sublingual immunotherapy treatment continues to gain momentum around the United States, it is important to note that all methods of sublingual immunotherapy are not following the same protocol nor have the same results. According to our La Crosse Method™ Practice Protocol, sublingual immunotherapy dosing is determined based on the individual's skin and/or blood test results; doses are administered multiple times a day; and allergens are preserved in high glycerin content. We believe this approach is the safest and most cost-effective option for the wide variety of allergic patients. Your allergy drop treatment is customized exactly to your needs; not too little antigen and not too much. We also believe it is best to address all of your allergies comprehensively. More than 99.9% of our active patient population has more than one allergy. By mixing allergens in a 50% glycerin solution, a preservative, we are able to treat multiple allergies at the same time without the allergens degrading or interacting with one another as they can with multi-allergen shot therapy.

We also find it important to take multiple daily doses. Studies show that once drops are placed under the tongue, the allergen stays in the sublingual area for up to 48 hours. From a technical standpoint, this allows for the specialized dendritic cells to interact with T cells—an important step for allergen desensitization. Multiple dosing is necessary in order to secure constant, uninterrupted exposure over time. Without multiple doses each day, the amount of antigen drops off until you deliver the next dose, similar to a peak and valley effect. Studies have also confirmed this effect. Bordignon et al. stated that, "the allergen persistence in the oral mucosa may be a far more relevant factor for gaining efficacy than allergen concentration." 1